Biological and immunological studies were performed on a child with severely impaired T-
cell function, normal B-cell function, and deficiency of nucleoside phosphorylase. Adenosine …

The results of immunotherapy and immunopathologic studies are described in a patient with
nucleoside phosphorylase deficiency, normal B cell function, and severe absence of T cell …

We studied a 15-month-old girl who had normal T-cell and B-cell immunity at birth, after
which a gradual decrease in T-cell immunity developed. This selective cellular …

Purine nucleoside phosphorylase deficiency in association with immunodeficiency is a
distinctive immunological disorder. A total of nine patients, in six different institutions, have …

Immune function in two brothers with a deficiency of purine nucleoside phosphorylase was
evaluated in vivo and in vitro. Both patients had a history of recurrent infections and …

A 5-year-old girl with a history of recurrent infection and anæmia has no measurable purine
nucleoside phosphorylase (NP) activity in her red blood-cells. Her serum-immunoglobulin …

Purine nucleoside phosphorylase (PNP) deficiency is associated with a severe defect in
thymus-derived (T)-lymphocyte function combined with normal bone marrow-derived (B) …

Immunologic and metabolic abnormalities were studied in a five year old boy with 0.07 per
cent of normal erythrocyte purine nucleoside phosphorylase activity. The clinical course is …

DEFICIENCY of the purine enzyme nucleoside phosphorylase is associated with a severe T-
lymphocyte immune deficiency. 1 2 3 4 5 6 The abnormality in the immune system results …

Purine nucleoside phosphorylase (NP EC 2.4. 2.1) deficiency in man is associated with
selective T cell dysfunction and normal B cell immunity. To create an in-vivo model of this …