On stimulation by the Fas ligand, the death receptor, Fas, initiates a signal leading to
apoptotic cell death. Fas plays an important role in physiological cell death and is closely …

Proteases of the caspase family, especially caspase-1 (ICE)(-like), caspase-3
(CPP32/Yama/apopain)(-like) and caspase-8 (MACH/FLICE/Mch5) proteases, are …

Caspase-1 (interleukin-1β converting enzyme) is produced in the form of a latent precursor,
which is cleaved to yield a prodomain in addition to the p20 and p10 subunits. It has been …

Abstract Background: Fas (APO-1/CD95) is a member of the tumor necrosis factor receptor
(TNF-R) family and induces apoptosis when crosslinked with either Fas ligand or agonistic …

It is now well established that the caspases, a family of cysteine proteases, play a key role in
apoptosis. Although overexpressing each of the caspases in cells triggered apoptosis, the …

Two novel synthetic tetrapeptides, VEID-CHO and DMQD-CHO, could selectively inhibit
caspase-6 and caspase-3, respectively. We used these inhibitors to dissect the pathway of …

We previously demonstrated that treatment with cycloheximide (CHX) converted the
phenotype of Fas-resistant human prostatic carcinoma cell lines to Fas-sensitive and that …

Apoptosis plays an important role in the dysfunction of exocrine glands. Fas is a death-
inducing receptor found on many types of cells including epithelial acinar cells. To elucidate …

The death mediator caspase acts as the dominant regulator during cell death induction. The
CPP32 subfamily, including caspase 3 (CPP32/Yama/Apopain), is essential for the cell …

We generated and characterized novel antibodies specific for a cleavage site of human
caspase-8/FLICE and its substrate, FLICE-like inhibitory protein (FLIP). The synthetic …