Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115
LG Kolik, TA Gudasheva, SB Seredenin - Bulletin of experimental biology …, 2012 - Springer
We studied the effect of dipeptide GB-115, a retroanalogue of cholecystokinin-4 with
anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced …
anxiolytic properties, on the behavior of outbred rats and BALB/c and C57Bl/6 mice induced …
Anxiolytic activity of dipeptide GB-115 after oral administration
LG Kolik, MA Konstantinopolsky, IV Ryibina… - Bulletin of experimental …, 2013 - Springer
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to
outbred and inbred animals with different level of emotionality, were studied in the open field …
outbred and inbred animals with different level of emotionality, were studied in the open field …
Role of different neurotransmitter systems in the cholecystokinin octapeptide-induced anxiogenic response in rats
E Biro, B Penke, G Telegdy - Neuropeptides, 1997 - Elsevier
The possible involvement of different neurotransmitter systems in the anxiogenic action of
cholecystokinin octapeptide sulphate ester (CCK-8) was investigated in rats …
cholecystokinin octapeptide sulphate ester (CCK-8) was investigated in rats …
Pharmacogenetic study of anxiolytic effects of new cholecystokinin receptor antagonists in animals with different levels of emotionality
LG Kolik, TA Gudasheva, SB Seredenin - Bulletin of Experimental Biology …, 2003 - Springer
Abstract Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101
(0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals …
(0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals …
Effect of the dipeptide retro-analog of cholecystokinin tetrapeptide (GB-115) on the behavior of rhesus monkeys in isolation
AV Panchenko, AV Panchenko… - Molekulyarnaya …, 2023 - journals.eco-vector.com
Introduction. The developed domestic dipeptide retro-analog of cholecystokinin (CCK)
tetrapeptide (N-(6-phenylhexanoyl)-glycyltryptophan amide, compound GB-115) with …
tetrapeptide (N-(6-phenylhexanoyl)-glycyltryptophan amide, compound GB-115) with …
Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection
SE Edeeva, GN Kopylova, ZV Bakaeva, GE Samonina… - 2008 - Springer
Experiments on outbred albino male rats showed that psychoemotional stress induced by
intraperitoneal injection of cholecystokinin-4 (100 µg/kg) increased anxiety, impaired …
intraperitoneal injection of cholecystokinin-4 (100 µg/kg) increased anxiety, impaired …
Anxiogenic effect of CCK8s in the ventral hippocampus of rats: possible involvement of GABA (A) receptors.
RS Hosseini, A Roohbakhsh - Pharmacological Reports: PR, 2012 - europepmc.org
Cholecystokinin (CCK) as an important neuropeptide in the brain has been implicated in the
modulation of anxiety. The effects of this neurotransmitter on anxiety-like behavior in the …
modulation of anxiety. The effects of this neurotransmitter on anxiety-like behavior in the …
Anxiogenic effect of CCK8s in the ventral hippocampus of rats: possible involvement of GABAA receptors
AH Moghaddam, RS Hosseini, A Roohbakhsh - Pharmacological Reports, 2012 - Springer
Cholecystokinin (CCK) as an important neuropeptide in the brain has been implicated in the
modulation of anxiety. The effects of this neurotransmitter on anxiety-like behavior in the …
modulation of anxiety. The effects of this neurotransmitter on anxiety-like behavior in the …
Systemic and intra-dorsal periaqueductal gray injections of cholecystokinin sulfated octapeptide (CCK-8s) induce a panic-like response in rats submitted to the …
JM Zanoveli, CF Netto, FS Guimarães, H Zangrossi Jr - Peptides, 2004 - Elsevier
The neuropeptide cholecystokinin (CCK) has been implicated in fear and anxiety. CCK is
found in the CNS in several molecular forms such as the tetrapeptide (CCK-4) and, mainly …
found in the CNS in several molecular forms such as the tetrapeptide (CCK-4) and, mainly …
The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze
P Chopin, M Briley - Psychopharmacology, 1993 - Springer
Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to
an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide …
an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide …