Specificity and correlation with disease activity of cerebrospinal fluid osteopontin levels in patients with multiple sclerosis
SA Chowdhury, J Lin, SA Sadiq - Archives of neurology, 2008 - jamanetwork.com
Background Despite recent advances in therapy that have improved the overall disease
course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable …
course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable …
Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
L Börnsen, M Khademi, T Olsson… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
[HTML][HTML] Osteopontin Is Associated with Multiple Sclerosis Relapses
M Stampanoni Bassi, F Buttari, L Gilio, E Iezzi, G Galifi… - Biomedicines, 2023 - mdpi.com
Background: Osteopontin, an extracellular matrix protein involved in bone remodeling,
tissue repair and inflammation, has previously been associated with increased inflammation …
tissue repair and inflammation, has previously been associated with increased inflammation …
Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development
P Kivisäkk, BC Healy, K Francois… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …
and immunity that has been suggested as a candidate biomarker for disease activity in …
Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis
M Braitch, R Nunan, G Niepel, LJ Edwards… - Archives of …, 2008 - jamanetwork.com
Objective To determine cerebrospinal fluid levels of osteopontin (OPN), a proinflammatory
cytokine that was found to be overexpressed in multiple sclerosis lesions and increased in …
cytokine that was found to be overexpressed in multiple sclerosis lesions and increased in …
Evaluating biomarkers of neuronal degeneration and neuroinflammation in CSF of patients with multiple sclerosis–osteopontin as a potential marker of clinical severity
Biomarkers capable of predicting the clinical course and the rate of disease progression in
multiple sclerosis are currently unavailable. Our objective was to examine if the levels of …
multiple sclerosis are currently unavailable. Our objective was to examine if the levels of …
Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers
MHJ Vogt, J ten Kate, RJM Drent… - Multiple Sclerosis …, 2010 - journals.sagepub.com
The pro-inflammatory cytokine osteopontin has been found to be highly expressed in
multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset …
multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset …
Plasma osteopontin levels in multiple sclerosis
M Comabella, I Pericot, R Goertsches, C Nos… - Journal of …, 2005 - Elsevier
Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
[HTML][HTML] Osteopontin levels are associated with late-time lower regional brain volumes in multiple sclerosis
G Orsi, Z Hayden, T Cseh, T Berki, Z Illes - Scientific Reports, 2021 - nature.com
Osteopontin (OPN) is a proinflammatory marker produced by systemic immune and central
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …
[HTML][HTML] Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis
Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …