Stabilization of mRNAs contributes to the strong and rapid induction of genes in the
inflammatory response. The signaling mechanisms involved were investigated using a …

An important determinant for the expression level of cytokines and proto-oncogenes is the
rate of degradation of their mRNAs. AU-rich sequence elements (AREs) in the 3 …

Adenylate/uridylate-rich element (ARE)-mediated mRNA turnover is an important regulatory
component of gene expression for innate and specific immunity, in the hematopoietic …

mRNA stability is a major determinant of inflammatory gene expression. Rapid degradation
of interleukin-8 (IL-8) mRNA is imposed by a bipartite AU-rich element (ARE) in the 3 …

AU-rich elements (AREs) in 3′-untranslated regions of mRNAs confer instability. They
target mRNAs for rapid deadenylation and degradation and may enhance decapping. The …

AU-rich elements (AREs), located in the 3′-untranslated region of unstable cytokine and
chemokine mRNAs, promote rapid decay of otherwise stable mRNAs and may mediate …

Extracellular-regulated kinases and p38 mitogen-activated protein kinases are activated in
innate (and adaptive) immunity and signal via different routes to alter the stability and …

Objective: To identify the site (s) in tumor necrosis factor (TNF α), interleukin-6 (IL-6), and
macrophage inflammatory protein-1 α (MIP-1 α) biosynthesis that is blocked by SB202190, a …

AU-rich elements (AREs) in the 3′-untranslated region (UTR) ofunstable mRNA dictate
their degradation or mediate translational repression. Cell signaling through p38α MAPK is …

The mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) plays a major role in
dephosphorylating and thereby inactivating the MAP kinases extracellular signal-regulated …