The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …

A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …

Synthetic and natural naphthofuranquinones were tested in vitro against three Trypanosoma
cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four …

Naphtho [2, 3-b] thiophen-4, 9-quinone and five derivatives were prepared using the Friedel-
Crafts reaction and tandem-lithiation of aromatic diethylamides. These quinones were …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …

The current chemotherapy for second stage human African trypanosomiasis is
unsatisfactory. A synthetic optimization study based on the lead antitrypanosomal compound …

Abstract A new indole-4, 9-dione and their phenoxy derivatives were synthesized and
evaluated in vitro against the epimastigote form of Trypanosoma cruzi, Y strain. All of these …

Eight novel analogues of Nifurtimox, 4-[(5-nitrofurfurylidene) amino]-3-methylthiomorpholine-
1, 1-dioxide, containing alfa–beta unsaturated amides, were synthesized and evaluated for …