The immune response contributes to ongoing secondary tissue destruction following spinal
cord injury (SCI). Although infiltrating neutrophils and monocytes have been well studied in …

Substantial progress has been made in the last several years in understanding why the
mammalian central nervous system (CNS) fails to regenerate after injury, and how the …

Cell-based therapy has been widely evaluated in spinal cord injury (SCI) animal models and
shown to improve functional recovery. However, host response to cell transplants at gene …

Spinal cord injury results in irreversible tissue damage followed by a very limited recovery of
function. In this study we investigated whether transplantation of undifferentiated human …

Rats have been the primary model to study the process and underlying mechanisms of
recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can …

It is likely that a combination of therapeutic interventions will be required to overcome spinal
cord injury and promote functional regeneration in higher vertebrates (including humans) …

Harmful and helpful roles of astrocytes in spinal cord injury (SCI): SCI induce gradable
sensory, motor and autonomic impairments that correlate with the lesion severity and the …

Background Central nervous system axons lack a robust regenerative response following
spinal cord injury (SCI) and regeneration is usually abortive. Supraspinal pathways, which …

Spinal cord injury (SCI) resulting from trauma decreases the quality of human life. Numerous
clues indicate that the limited endogenous regenerative potential is a result of the interplay …