Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects

D Li, P Hu, S Xu, C Fang, S Tang, X Wang… - Archives of Pharmacal …, 2017 - Springer
Herein, a series of lasiokaurin derivatives were designed and synthesized. All the
derivatives together with lasiokaurin and oridonin were tested for their antimicrobial and …

[HTML][HTML] Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma

QF Zou, JK Du, H Zhang, HB Wang, ZD Hu… - Journal of translational …, 2013 - Springer
Background Longikaurin A is a natural ent-kaurene diterpenoid isolated from Isodon genus.
The ent-kaurene diterpenoids isolated from medicinal plants have been shown to have anti …

[HTML][HTML] Exploring the in vitro and in vivo anticancer activity of lasiokaurin on nasopharyngeal carcinoma

H Pu, J Lin, LS Shen, YS Lin, RH Gong… - Pharmacological …, 2023 - Elsevier
Objective To evaluate the anticancer activity of the natural diterpenoid lasiokaurin (LAS)
against nasopharyngeal carcinoma (NPC) both in vitro and in vivo, along with investigating …

Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents

XL Xu, JX Lan, H Huang, W Dai, XP Peng… - Bioorganic & Medicinal …, 2023 - Elsevier
Cancer with low survival rates is the second main cause of death among all diseases in the
world and consequently, effective antineoplastic agents are urgently needed. Allosecurinine …

Apoptotic effect of jaceosidin on MCF-7 human breast cancer cells through modulation of ERK and p38 MAPK pathways

OV Ojulari, JB Chae, SG Lee, K Min… - Natural Product …, 2021 - Taylor & Francis
Jaceosidin a flavone abundant in Artemisia species has been used for its beneficial effects.
This study investigated the apoptotic effect of jaceosidin treatment on MCF-7 human breast …

[HTML][HTML] Ellagic acid promotes A549 cell apoptosis via regulating the phosphoinositide 3‑kinase/protein kinase B pathway

Q Liu, X Liang, C Niu, X Wang - Experimental and …, 2018 - spandidos-publications.com
The present study aimed to evaluate the anti‑cancer effect of ellagic acid in human non‑
small cell lung cancer (NSCLC) A549 cells and to reveal the potential underlying …

Calotropin from Asclepias curasavica induces cell cycle arrest and apoptosis in cisplatin-resistant lung cancer cells

EP Mo, RR Zhang, J Xu, H Zhang, XX Wang… - Biochemical and …, 2016 - Elsevier
Abstract Calotropin (M11), an active compound isolated from Asclepias curasavica L., was
found to exert strong inhibitory and pro-apoptotic activity specifically against cisplatin …

[HTML][HTML] Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis

J Liu, WX Hu, LF He, M Ye, Y Li - FEBS letters, 2004 - Elsevier
As a natural anti-cancer alkaloid extracted from Amaryllidaceae, lycorine shows various
biological effects on tumor cells. The survival rate of HL-60 cells exposed to lycorine was …

[HTML][HTML] Jaceosidin inhibits proliferation of human bladder cancer T24 cells through induction of cell cycle arrest and apoptosis

Y Li, Y Tan - ||| Bangladesh Journal of Pharmacology|||, 2013 - bdpsjournal.org
Jaceosidin, isolated from Artemesia argyi, has been shown to possess promising anticancer
potential against various cancer cells. However, its effect against bladder cancer cells …

Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells

KY Kim, SH Kim, SN Yu, SG Park, YW Kim… - Biomedicine & …, 2017 - Elsevier
Lasalocid is an antibiotic from the group of carboxylic ionophores, produced by
Streptomyces lasaliensis. But there was limited information of lasalocid on human prostate …