Contribution of AMPA receptor-mediated LTD in LA/BLA-CeA pathway to comorbid aversive and depressive symptoms in neuropathic pain
H Jiang, JP Liu, K Xi, LY Liu, LY Kong… - Journal of …, 2021 - Soc Neuroscience
Comorbid anxiety and depressive symptoms in chronic pain are a common health problem,
but the underlying mechanisms remain unclear. Previously, we have demonstrated that …
but the underlying mechanisms remain unclear. Previously, we have demonstrated that …
[HTML][HTML] Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain …
H Jiang, D Fang, LY Kong, ZR Jin, J Cai, XJ Kang… - Molecular brain, 2014 - Springer
Background Despite high prevalence of anxiety accompanying with chronic pain, the
mechanisms underlying pain-related anxiety are largely unknown. With its well-documented …
mechanisms underlying pain-related anxiety are largely unknown. With its well-documented …
Chronic stress exacerbates neuropathic pain via the integration of stress-affect–related information with nociceptive information in the central nucleus of the amygdala
MJ Li, LY Liu, L Chen, J Cai, Y Wan, GG Xing - Pain, 2017 - journals.lww.com
Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric
disorders, including anxiety and depression, represent significant clinical challenges …
disorders, including anxiety and depression, represent significant clinical challenges …
[HTML][HTML] An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain
S He, X Huang, J Zheng, Y Zhang, X Ruan - Neurobiology of Disease, 2022 - Elsevier
Depressive symptoms comorbid with chronic pain are a common health problem, but the
underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic …
underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic …
[HTML][HTML] Rostral anterior cingulate cortex–ventrolateral periaqueductal gray circuit underlies electroacupuncture to alleviate hyperalgesia but not anxiety-like behaviors …
X Zhu, Y Xu, Z Shen, H Zhang, S Xiao, Y Zhu… - Frontiers in …, 2022 - frontiersin.org
Neuropathic pain is a common cause of chronic pain and is often accompanied by negative
emotions, making it complex and difficult to treat. However, the neural circuit mechanisms …
emotions, making it complex and difficult to treat. However, the neural circuit mechanisms …
Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
Cortical areas including the anterior cingulate cortex (ACC) are important for pain and
pleasure. Recent studies using genetic and physiological approaches have demonstrated …
pleasure. Recent studies using genetic and physiological approaches have demonstrated …
[HTML][HTML] Dysfunction of glutamate delta-1 receptor-cerebellin 1 trans-synaptic signaling in the central amygdala in chronic pain
Chronic pain is a debilitating condition involving neuronal dysfunction, but the synaptic
mechanisms underlying the persistence of pain are still poorly understood. We found that …
mechanisms underlying the persistence of pain are still poorly understood. We found that …
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice
Z Chen, C Su, S Xiong, T Li, H Liang, Y Lin… - Acta Pharmacologica …, 2023 - nature.com
Chronic pain patients often have anxiety disorders, and some of them suffer from anxiety
even after analgesic administration. In this study, we investigated the role of AMPAR …
even after analgesic administration. In this study, we investigated the role of AMPAR …
Role of extracellular signal-regulated kinase in synaptic transmission and plasticity of a nociceptive input on capsular central amygdaloid neurons in normal and acid …
SJ Cheng, CC Chen, HW Yang, YT Chang… - Journal of …, 2011 - Soc Neuroscience
Application of phorbol 12, 13-diacetate (PDA) caused marked enhancement of synaptic
transmission of nociceptive parabrachio-amygdaloid (PBA) input onto neurons of the …
transmission of nociceptive parabrachio-amygdaloid (PBA) input onto neurons of the …
Calcium-permeable AMPA receptors in the nucleus accumbens regulate depression-like behaviors in the chronic neuropathic pain state
Depression is a salient emotional feature of chronic pain. Depression alters the pain
threshold and impairs functional recovery. To date, however, there has been limited …
threshold and impairs functional recovery. To date, however, there has been limited …