Calcium signaling critical to neural functions is mediated through Ca2+ channels localized
on both the plasma membrane and intracellular organelles such as endoplasmic reticulum …

Ryanodine receptors (RyR) are Ca2+-induced Ca2+ release channels located on the
endoplasmic reticulum, and consist of three isoforms, termed RyR1-3. We examined their …

Deletion of the ryanodine receptor type 3 (RyR3) results in specific changes in hippocampal
synaptic plasticity, without affecting hippocampal morphology, basal synaptic transmission …

Neuronal L-type Ca 2+ channels do not support synaptic transmission, but they play an
essential role in synaptic activity-dependent gene expression. Ca v 1.2 and Ca v 1.3 are the …

The hippocampus is a brain region implicated in synaptic plasticity and memory formation;
both processes require neuronal Ca 2+ signals generated by Ca 2+ entry via plasma …

The expression of several hippocampal genes implicated in learning and memory
processes requires that Ca2+ signals generated in dendritic spines, dendrites, or the soma …

The neuronal Ca2+ signal is induced by a rise in the intracellular free Ca2+ concentration
([Ca2+] i), and is thought to be important for higher brain function. Dynamic changes in …

Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced
Ca2+ release in response to activity-generated Ca2+ influx play a significant role in …

Cellular Ca2+ signalling is an important factor in the control of neuronal metabolism and
electrical activity. Although the roles of Ca2+-release channels are well established for …

The administration of the ryanodine receptor (RyR) agonist 4-Cmc (0.003–9 nmol per mouse
intracerebroventricularly [icv]) ameliorated memory functions, whereas the RyR antagonist …