Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis [S]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …
Forced hepatic overexpression of CEACAM1 curtails diet-induced insulin resistance
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
Hepatic CEACAM1 over-expression protects against diet-induced fibrosis and inflammation in white adipose tissue
SG Lester, L Russo, SS Ghanem, SS Khuder… - Frontiers in …, 2015 - frontiersin.org
CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying
global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat (HF) diet exhibited …
global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat (HF) diet exhibited …
Reduced hepatic carcinoembryonic antigen-related cell adhesion molecule 1 level in obesity
G Heinrich, HT Muturi, K Rezaei, QY Al-Share… - Frontiers in …, 2017 - frontiersin.org
Impairment of insulin clearance is being increasingly recognized as a critical step in the
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …
Loss of hepatic CEACAM1: a unifying mechanism linking insulin resistance to obesity and non-alcoholic fatty liver disease
G Heinrich, HE Ghadieh, SS Ghanem… - Frontiers in …, 2017 - frontiersin.org
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis
HE Ghadieh, L Russo, HT Muturi, SS Ghanem… - Metabolism, 2019 - Elsevier
Background CEACAM1 regulates insulin sensitivity by promoting insulin clearance.
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
L Russo, HT Muturi, HE Ghadieh, SS Ghanem… - Diabetologia, 2017 - Springer
Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
PPARα (peroxisome proliferator-activated receptor α) activation reduces hepatic CEACAM1 protein expression to regulate fatty acid oxidation during fasting-refeeding …
SK Ramakrishnan, SS Khuder, QY Al-Share… - Journal of Biological …, 2016 - ASBMB
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed at
high levels in the hepatocyte, consistent with its role in promoting insulin clearance in liver …
high levels in the hepatocyte, consistent with its role in promoting insulin clearance in liver …
Mice with null mutation of Ceacam1 develop nonalcoholic steatohepatitis
S Ghosh, M Kaw, PR Patel, KJ Ledford… - Hepatic medicine …, 2010 - Taylor & Francis
Transgenic liver-specific inactivation of the carcinoembryonic antigen-related cell adhesion
molecule (CEACAM1) impairs hepatic insulin clearance and causes hyperinsulinemia …
molecule (CEACAM1) impairs hepatic insulin clearance and causes hyperinsulinemia …
Reversal of obesity development in Ceacam1−/− male mice by bone marrow transplantation or introduction of the human CEACAM1 gene
Z Zhang, D La Placa, G Gugiu, A Thunen, K Le… - …, 2022 - Wiley Online Library
Abstract Objective Although Ceacam1−/− male mice become obese on normal chow, the
effect of bone marrow transplantation or introduction of the carcinoembryonic antigen …
effect of bone marrow transplantation or introduction of the carcinoembryonic antigen …