Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …

After infection, many factors coordinate the population expansion and differentiation of CD8+
effector and memory T cells. Using data of unparalleled breadth from the Immunological …

Immunological memory and exhaustion are fundamental features of adaptive immunity.
Recent advances reveal increasing heterogeneity and diversity among CD8 T-cell subsets …

In response to acute infections or vaccines, naive antigen‐specific CD8+ T cells proliferate
and differentiate into effector cytotoxic lymphocytes that acquire the ability to kill infected …

One outcome of infection is the formation of long-lived immunological memory, which
provides durable protection from symptomatic re-infection. In response to infection or …

Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

Immune responses to infection are optimally designed to generate large numbers of effector
T cells while simultaneously minimizing the collateral damage of their potentially lethal …

An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …