A search of the literature using National Library of Medicine databases and individual
cancer journal articles yielded over 500 compounds with published chemopreventive activity …

Chemoprevention drug development has the goal of identifying safe and effective
chemopreventive agents for clinical use. Several distinctive strategies are pursued in …

Clinical chemoprevention trials of more than 30 agents and agent combinations are now in
progress or being planned. The most advanced agents are well known and are in large …

Abstract In the NCI, Chemoprevention Branch drug development program, potential
chemopreventive agents are evaluated for efficacy against chemical carcinogen–induced …

Chemoprevention of cancer is reviewed from the viewpoints of action mechanisms and
methodology of clinical trials in order to introduce promising agents discovered by in vitro …

In the late 20th century, the treatment of cancer began to include its prevention. Today,
compounds exist that will lower the risk of developing certain types of cancer. This has been …

Ninety potential chemopreventive agents were screened using 6 chemoprevention-
associated biochemical end points. These compounds were tested using rodent (tracheal …

Cancer chemoprevention can be defined as prevention of cancer by the administration of
one or more chemical entities, either as individual drugs or as naturally occurring …

This is the second publication of Clinical Development Plans from the National Cancer
Institute, Division of Cancer Prevention and Control, Chemoprevention Branch and Agent …

Abstract The Chemoprevention Branch is testing dozens of candidate chemopreventive
compounds in the following rodent model carcinogenesis systems: mouse skin papillomas …