Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by
numerous adverse effects. Of greatest concern is AM-induced pulmonary toxicity (AIPT) due …

Associated with amiodarone (AM) therapy is pneumonitis, which may progress to life-
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …

Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of
interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To …

Associated with amiodarone use is pneumonitis which may progress to life-threatening
pulmonary fibrosis. Desethylamiodarone, a metabolite, whose role in the etiology of …

Amiodarone (AMI), a widely used, effective anti‐arrhythmic drug, has severe side effects,
including acute lung toxicity and pulmonary fibrosis. Our aim is to test the hypothesis that a …

Amiodarone, an antiarrhythmic drug toxic toward the lung, is metabolized through sequential
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …

Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …

Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …

Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …