Western societies are aging due to an increasing life span, decreased birth rates, and
improving social and health conditions. On the other hand, the prevalence of cardiovascular …

Vascular aging, characterized by structural and functional alterations of the vascular wall, is
a hallmark of aging and is tightly related to the development of cardiovascular mortality and …

Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …

Ageing leads to a progressive deterioration of structure and function of all organs over the
time. During this process endothelial cells undergo senescence and manifest significant …

The incidence and prevalence of cardiovascular disease is highest among the elderly, in
part, due to deleterious effects of advancing age on the heart and blood vessels. Aging, a …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Abstract “Inside every old person is a young person wondering what happened.” So, what is
aging? Aging is a manifestation of progressive, time-dependent failure of molecular …

Aging results in functional and structural changes in the cardiovascular system, translating
into a progressive increase of mechanical vessel stiffness, due to a combination of changes …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Age-related pathological alterations of the vasculature have a critical role in morbidity and
mortality of older adults. In epidemiological studies, age is the single most important …