Development and characterization of an animal model of severe pulmonary arterial hypertension

Y Morimatsu, N Sakashita, Y Komohara… - Journal of vascular …, 2011 - karger.com
Pulmonary arterial hypertension (PAH) is a serious pathological phenomenon with poor
prognosis, which is associated with morphological as well as hemodynamic alteration of the …

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

KR Stenmark, B Meyrick, N Galie… - … of Physiology-Lung …, 2009 - journals.physiology.org
At present, six groups of chronic pulmonary hypertension (PH) are described. Among these,
group 1 (and 1′) comprises a group of diverse diseases termed pulmonary arterial …

[HTML][HTML] Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

F Coste, C Guibert, J Magat, E Abell, F Vaillant… - Respiratory …, 2017 - Springer
Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that
combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and …

Chronic hypoxia-induced pulmonary hypertension in rat: the best animal model for studying pulmonary vasoconstriction and vascular medial hypertrophy

L Zhao - Drug discovery today: disease models, 2010 - Elsevier
Numerous animal models of pulmonary hypertension (PH) are currently used to evaluate
new therapies; investigating both their efficacy and the mechanism of their effect. They are …

[HTML][HTML] Hemodynamic characterization of rodent models of pulmonary arterial hypertension

Z Ma, L Mao, S Rajagopal - Journal of visualized experiments …, 2016 - ncbi.nlm.nih.gov
Pulmonary arterial hypertension (PAH) is a rare disease of the pulmonary vasculature
characterized by endothelial cell apoptosis, smooth muscle proliferation and obliteration of …

Animal models of pulmonary arterial hypertension

R Naeije, L Dewachter - Revue des maladies respiratoires, 2007 - europepmc.org
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a rare syndrome of fatigue and
dyspnoea, caused by increased pulmonary vascular resistance and right heart failure …

MicroCT analysis of vascular morphometry: a comparison of right lung lobes in the SUGEN/hypoxic rat model of pulmonary arterial hypertension

EM Faight, K Verdelis, L Zourelias… - Pulmonary …, 2017 - journals.sagepub.com
Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant
vascular remodeling within the lung. Clinical computed tomography (CT) scans are routinely …

Rodent models of group 1 pulmonary hypertension

JJ Ryan, G Marsboom, SL Archer - Pharmacotherapy of pulmonary …, 2013 - Springer
Abstract World Health Organization category 1 pulmonary hypertension (PH) is a
heterogeneous syndrome in which PH originates in the small pulmonary arteries and is …

[HTML][HTML] Advancing therapy for pulmonary arterial hypertension: can animal models help?

IM Robbins - American journal of respiratory and critical care …, 2004 - atsjournals.org
Pulmonary arterial hypertension (PAH) is a disorder predominantly affecting the small
pulmonary arteries. It can occur without an identifiable cause, primary pulmonary …

A novel murine model of severe pulmonary arterial hypertension

L Ciuclan, O Bonneau, M Hussey… - American journal of …, 2011 - atsjournals.org
Rationale: The complex pathologies associated with severe pulmonary arterial hypertension
(PAH) in humans have been a challenge to reproduce in mice due to the subtle phenotype …