Fat is now considered as an endocrine organ that produces a lot of molecules having
biological activity, called adipocytokines. Among these, adiponectin, a 247 aminoacid …

The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic
diseases. Adipose cells produce both proteins and release them into the circulation. Leptin …

Adipose tissue is a highly dynamic endocrine organ, secreting a number of bioactive
substances (adipokines) regulating insulin sensitivity, energy metabolism and vascular …

Adipose tissue is an active metabolic tissue that secretes multiple metabolically important
proteins, known as adipokines. Adiponectin is an important adipokine because of its …

A large number of studies revealed that adiponectin, a protein secreted specifically by
adipose tissue, exhibits antiinflammatory, antiatherogenic, and antidiabetic properties. This …

Adiponectin is a recently described adipokine that has been recognized as a key regulator
of insulin sensitivity and tissue inflammation. It is produced by adipose tissue (white and …

Recently, adipocytes have been shown to be endocrine cells that secrete a variety of
bioactive substances-the so-called adipocytokines. Among adipocytokines, tumor …

Circulating adiponectin concentrations are reduced in obese individuals, and this reduction
has been proposed to have a crucial role in the pathogenesis of atherosclerosis and …

Hypertension is a major risk factor for cardiovascular disease, and the latter is the leading
cause of morbidity and mortality worldwide. In developed countries, hypertension ranks as …

Adiponectin is an adipocyte‐derived hormone that was discovered in 1995. Unlike leptin,
which was identified around the same time, the clinical relevance of adiponectin remained …