Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

T Yamauchi, T Kadowaki - International journal of obesity, 2008 - nature.com
Adiponectin and adiponectin receptors (AdipoRs) have been found to play significant roles
in the etiology of obesity-related chronic disease. Their discovery has been a long and …

Adiponectin action from head to toe

K Brochu-Gaudreau, C Rehfeldt, R Blouin, V Bordignon… - Endocrine, 2010 - Springer
Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its
involvement in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus …

Adiponectin: a key player in obesity related disorders

Y Matsuzawa - Current pharmaceutical design, 2010 - ingentaconnect.com
Recent studies revealed that adipose tissue is not only an energy storing organ, but is a kind
of endocrine organ which secretes a variety of bioactive substances, so-called adipokines or …

The role of the novel adipocyte-derived hormone adiponectin in human disease

JJ Diez, P Iglesias - European Journal of endocrinology, 2003 - academic.oup.com
Abstract Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is a novel adipose
tIssue-specific protein that has structural homology to collagen VIII and X and complement …

Adiponectin is associated with increased mortality in patients with already established cardiovascular disease: a systematic review and meta-analysis

ZJ Wu, YJ Cheng, WJ Gu, LHH Aung - Metabolism, 2014 - Elsevier
Background The overall quantitative estimate on the possible association of adiponectin
concentrations with mortality in patients with cardiovascular diseases (CVD) has not been …

Adiponectin as a biomarker of the metabolic syndrome

M Ryo, T Nakamura, S Kihara, M Kumada… - Circulation …, 2004 - jstage.jst.go.jp
Background The metabolic syndrome, a cluster of abdominal obesity, dyslipidemia,
hypertension and hyperglycemia, is a common basis for atherosclerotic vascular diseases in …

Adiponectin in cardiovascular inflammation and obesity

TR Aprahamian, F Sam - International journal of inflammation, 2011 - Wiley Online Library
Inflammation is widely known to play a key role in the development and progression of
cardiovascular diseases. It is becoming increasingly evident that obesity is linked to many …

Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease

A Xu, PM Vanhoutte - American Journal of Physiology …, 2012 - journals.physiology.org
The heart and blood vessels are surrounded by epicardial and perivascular adipose tissues,
respectively, which play important roles in maintaining cardiovascular homeostasis by …

Adiponectin represents an independent cardiovascular risk factor predicting serum HDL‐cholesterol levels in type 2 diabetes

B Zietz, H Herfarth, G Paul, A Ehling… - FEBS …, 2003 - Wiley Online Library
Low levels of high‐density lipoprotein (HDL)‐cholesterol represent an independent
cardiovascular risk factor and, besides reduced physical activity, mechanisms leading to …

Adiponectin—it's all about the modifications

F Simpson, JP Whitehead - The international journal of biochemistry & cell …, 2010 - Elsevier
Adiponectin is an adipokine (adipocyte-derived hormone) with multiple salutary effects. It is
secreted into the circulation as low molecular weight (LMW) and high molecular weight …