Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model

SH Lee, YH Chen, CC Chien, YH Yan, HC Chen… - PLoS …, 2021 - journals.plos.org
Although numerous epidemiological studies revealed an association between ambient fine
particulate matter (PM2. 5) exposure and Alzheimer's disease (AD), the PM2. 5-induced …

Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route

C Liang, Y Jiang, T Zhang, Y Ji, Y Zhang, Y Sun… - Science of The Total …, 2023 - Elsevier
Atmospheric particulate matter (PM), a ubiquitous air pollutant, is the leading environmental
risk factor for mortality worldwide. Experimental and epidemiological studies consistently …

A review of the possible associations between ambient PM2. 5 exposures and the development of Alzheimer's disease

Y Shou, Y Huang, X Zhu, C Liu, Y Hu… - … and Environmental Safety, 2019 - Elsevier
PM2. 5 particles in air pollution have been widely considered associated with respiratory
and cardiovascular diseases. Recent studies have shown that PM2. 5 can also cause …

An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models

YJ Kang, HY Tan, CY Lee, H Cho - Advanced Science, 2021 - Wiley Online Library
Abstract Fine particulate matter (PM2. 5), a major component among air pollutants,
highlights as a global health concern. Several epidemiological studies show the correlation …

Ambient PM2. 5 chronic exposure leads to cognitive decline in mice: From pulmonary to neuronal inflammation

Y Shou, X Zhu, D Zhu, H Yin, Y Shi, M Chen, L Lu… - Toxicology letters, 2020 - Elsevier
Abstract Fine particulate matter 2.5 (PM 2.5), one of the main components of air pollutants,
seriously threatens human health. Possible neuronal dysfunction induced by PM 2.5 has …

Exposure to PM2. 5 induces neurotoxicity, mitochondrial dysfunction, oxidative stress and inflammation in human SH-SY5Y neuronal cells

CH Lin, CJB Nicol, C Wan, SJ Chen, RN Huang… - Neurotoxicology, 2022 - Elsevier
Ambient air pollution is a global public health issue. Recent evidence suggests that
exposure to fine aerosolized particulate matter (PM) as small as≤ 2.5 microns (PM 2.5) is …

A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain

DP Bhatt, KL Puig, MW Gorr, LE Wold, CK Combs - PLoS One, 2015 - journals.plos.org
Exposure to air pollutants, including particulate matter, results in activation of the brain
inflammatory response and Alzheimer disease (AD)-like pathology in dogs and humans …

Neurodevelopmental toxicity induced by PM2. 5 Exposure and its possible role in Neurodegenerative and mental disorders

X Liu, J Huang, C Song, T Zhang… - Human & …, 2023 - journals.sagepub.com
Recent extensive evidence suggests that ambient fine particulate matter (PM2. 5, with an
aerodynamic diameter≤ 2.5 μm) may be neurotoxic to the brain and cause central nervous …

[HTML][HTML] At seeming safe concentrations, synergistic effects of PM2. 5 and formaldehyde co-exposure induces Alzheimer-like changes in mouse brain

X Liu, Y Zhang, C Luo, J Kang, J Li, K Wang, P Ma… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a serious, common, global disease, yet its etiology and
pathogenesis are incompletely understood. Air pollution is a multi-pollutants co-exposure …

Comprehensive hippocampal metabolite responses to PM2. 5 in young mice

X Ning, B Li, T Ku, L Guo, G Li, N Sang - Ecotoxicology and Environmental …, 2018 - Elsevier
Abstract Fine particulate matter (PM 2.5) exposure alters brain development, clinical
cognition and behavior in childhood. Previous studies of this subject have mainly been …