Atomic resolution structures are now available for more than 20 complexes of proteins with
specific RNAs. This review examines two main themes that appear in this set of structures. A …

The past few years have witnessed remarkable progress in knowledge of the structure and
function of RNA-binding proteins and their RNA complexes. X-ray crystallography and NMR …

This minireview series examines the structural principles underlying the biological function
of RNA‐binding proteins. The structural work of the last decade has elucidated the structures …

Metazoan genomes encode hundreds of RNA-binding proteins (RBPs) but RNA-binding
preferences for relatively few RBPs have been well defined. Current techniques for …

From transcription, to transport, storage, and translation, RNA depends on association with
different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and …

Background RNA molecules play a central role in all the main functions of living molecules:
storage of genetic information, propagation of the genetic material, and enzymatic activity …

When RNA and protein bind each other, recognition occurs almost invariably by “induced fit”
rather than by rigid “lock-and-key” docking (1, 2). The protein, the RNA, and sometimes both …

Members of a family of proteins containing a conserved∼ 80-amino acid RNA recognition
motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in …

Two generalizations can be drawn from the recent rapid progress in understanding RNA–
protein interactions. First, there is a great diversity of observed protein and RNA structural …

The study of proteins that bind to RNA-many of them mediators of gene expression or its
regulation-has led to the identification of several protein families. Each family is …