Aging is a major risk factor for numerous human pathologies, including cardiovascular,
metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies …

Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …

Cellular senescence is a physiological phenomenon that has both beneficial and
detrimental consequences. Senescence limits tumorigenesis and tissue damage throughout …

Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …