The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory
actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been …

Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is
implicated in neuronal survival on the basis that mutations in the GRN gene causing …

Mutations in progranulin gene (GRN) are one of the major causes of autosomal dominant
Frontotemporal Lobar Degeneration (FTLD). Progranulin displays anti-inflammatory …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …

Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In
humans, PGRN haploinsufficiency is a major inherited cause of frontotemporal dementia …

Progranulin is a widely expressed protein that is involved in the regulation of multiple
biological processes, including embryogenesis, host defense, and wound repair. In the …

Progranulin (PGRN) is a widely expressed protein involved in diverse biological processes.
Haploinsufficiency of PGRN in the human causes tau-negative, ubiquitin-positive …

It is well known that progranulin protein is involved in wound repair, inflammation, and tumor
formation. The wedding between progranulin and brain was celebrated in 2006 with the …

Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …