Natural autoantibodies/natural autoimmunity forms a network that serves to protect the
organism from outer and inner danger but may also contribute to autoimmune disease. This …

Autoantibodies are common in healthy individuals and appear not to be harmful. It is not
clear how they arise nor what their function is. Here Irun Cohen and Anne Cooke propose …

Since Burnet first introduced his “forbidden clones” theory, the discrimination between self
and non-self and the physiologic mechanisms of avoiding autoimmunity remained an …

The immune system of normal unimmunized animals is characterized by the presence of B
cells synthesizing and secreting mainly polyreactive, but also monoreactive, IgM and IgG …

Natural autoantibodies (NAA) are self-reacting antibodies found in the serum. NAA do not
require antigenic or mitogenic stimuli for their synthesis. These low affinity antibodies are …

According to Burnet's clonal selection theory,'in the early 1960s, explanations for tolerance
and autoimmunity were attractively simple. Autoreactive lymphocytes were deleted during …

A substantial proportion of circulating antibodies in healthy individuals exhibit self-reactivity.
These antibodies, referred to as natural autoantibodies, are thought to arise naturally without …

Natural autoantibodies (autoNAb) recognize self antigens and are an important component
of the immune system, as species ranging from invertebrates to vertebrates have …

Autoimmunity is mediated by a variety of mechanisms, molecular and cellular events, and
responses. Predisposition to a given autoimmune response requires the requisite allele (s) …

This is the first book to address all aspects of the biology of autoantibodies in a single
volume, including a discussion of immunology, experimental models, clinical aspects, and …