Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein
(LDL) cholesterol-lowering activity. We conducted 2 dose-ranging studies. In the first study …

Background: Although most patients with hypercholesterolemia require life-long therapy with
statins, these drugs are underused due to high costs. Every-other-day therapy could be one …

The lipid-lowering effects of rosuvastatin and atorvastatin were determined across their dose
ranges in a 6-week, randomized, double-blind trial. Three hundred seventy-four …

Objective: To examine the efficacy and tolerability of rosuvastatin 5 mg at daily and non-daily
dosing regimens. Research design and methods: A retrospective survey was conducted at …

Simvastatin, as well as most of the other statins, is recommended given as a single dose in
the evening. 1 This is due to the diurnal variation in liver cholesterol synthesis peaking at …

A total of 5 randomized, double-blind trials in patients with hypercholesterolemia were
prospectively designed to allow pooling of plasma lipid data after 12 weeks of treatment. The …

A total of 291 patients with primary hypercholesterolemia [total plasma cholesterol≥ 6.20
mmol/liter (≥ 240 mg/dl)] were enrolled in an open, randomized, parallel, comparative study …

The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter
trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose …

The efficacy and safety profile of simvastatin and pravastatin across their most commonly
recommended dosage ranges were compared in a doubleblind, parallel, multicenter study …

Numerous studies have demonstrated that treatments designed to reduce low‐density
lipoprotein cholesterol (LDL‐C) can reduce the risk of coronary heart disease (CHD) events …