One hundred patients with primary hypercholesterolemia (total plasma cholesterol greater
than or equal to 6.2 mmol/L [240 mg/dl]) were enrolled in an open, randomized, parallel …

BACKGROUND: Alternative dosing is often used clinically to address common barriers with
statin therapy, such as intolerance and cost. Previous findings have demonstrated significant …

Rosuvastatin, a new hydrophilic 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase
inhibitor (statin), is approved as an adjunct to diet in patients with primary …

Background and Objectives Although the rate of prescribing hydroxylmethyglutaryl-CoA
reductase inhibitors (statin) has recently increased, there is a large treatment gap between …

2Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin,
Hong Kong 3Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital …

New information on the tolerability of lovastatin has emerged from an ongoing study of long-
term therapy; preliminary results from a large, 48-week clinical trial; and spontaneous …

We directly compared the safety and efficacy of atorvastatin and simvastatin in
hypercholesterolemic patients. This 1-year, randomized, double-blind study was performed …

Statins are administered daily, but because of their long half‐lives, atorvastatin and
rosuvastatin can be given every other day (qod). We examined the effect of qod statin …

1. Describe the basic design and purpose of the Justification for the Use of Statins in
Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial.

Objective The primary objective of this trial was to compare the efficacy of rosuvastatin with
that of pravastatin and simvastatin for lowering low-density lipoprotein cholesterol (LDL-C) …