Abstract Simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, has
been administered to approximately 2,400 patients with primary hypercholesterolemia with a …

Time of administration is another factor, the optimal time for most statins being the evening,
reflecting the diurnal rhythm of HMG CoA reductase activity; reductions in LDL cholesterol …

This analysis assessed the safety of atorvastatin in the 10-to 80-mg dose range using
pooled data from 44 completed trials comprising 16,495 dyslipidemic patients treated with …

This randomized, double-blind, placebo-controlled trial was conducted in 52 centers in
North America to compare the effects of the new, highly effective statin, rosuvastatin, with …

Previous studies have shown that simvastatin, a hydroxymethyl glutaryl coenzyme A
reductase inhibitor, reduces plasma cholesterol levels when administered once a day. In the …

Purpose. The chemistry, pharmacology, pharmacokinetics, drug interactions, clinical
efficacy, adverse effects, dosage and administration, and place in therapy of rosuvastatin are …

Background: Simvastatin and atorvastatin are effective statins for treating
hypercholesterolemia. Hypothesis: The study was undertaken to compare the efficacy and …

Rosuvastatin is a synthetic enantiomer that is hepatoselective, relatively hydrophilic and has
minimal metabolism via the cytochrome P450 3A4 system (similar to pravastatin) …

BACKGROUND/AIM: Statin intolerance is increasingly recognized as a therapy limiting
factor in the primary and secondary prevention of cardiovascular disease. Since vulnerability …

Recent observations suggest that the risk of adverse events may differ among thee various
statins. Our present findings support a specific difference in the risk of developiong an …