Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and
endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate …

Inflammation contributes to the pathogenesis of most acute and chronic liver diseases.
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …

Tissue stress and cell death result in inflammation even in the absence of pathogens. Such
sterile inflammation is dependent on a cytosolic complex of proteins inside immune cells …

Inflammation is a common element in the pathogenesis of most chronic liver diseases that
lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune …

Liver cirrhosis develops as a result of persistent inflammation and liver injury. The prolonged
inflammation triggers the buildup of fibrous tissue and regenerative nodules within the liver …

The liver possesses a strong inflammatory response, as seen experimentally and clinically
with liver inflammation due to toxic and metabolic stress, sepsis and ischemia. Initiation of …

Inflammasomes have emerged as critical innate sensors of host immune that defense
against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in …

Both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease are characterized by
massive lipid accumulation in the liver accompanied by inflammation, fibrosis, cirrhosis, and …

The involvement of inflammasomes in the proinflammatory response observed in chronic
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …

Inflammation and tumorigenesis are tightly linked pathways impacting cancer development.
Inflammasomes are key signalling platforms that detect pathogenic microorganisms …