There are two basic mechanisms for the uptake of substances into the cell. Small molecules
such as amino acids, mono-saccharides, and most ions are transported directly across the …

Publisher Summary This chapter discusses the intracellular traffic of the asialoglycoprotein
(ASGP) receptor and its ligands and integrates this information into the current …

Publisher Summary The cell biology and biochemistry of the asialoglycoprotein receptor
(ASGP-R) system provide unique insights into the fundamental process of receptor …

The major subunit of the human asialoglycoprotein receptor contains signals for efficient
endocytosis and specific basolateral expression in polarized Madin-Darby canine kidney …

Signals for endocytosis and for basolateral and lysosomal sorting are closely related in a
number of membrane proteins, suggesting similar sorting mechanisms at the plasma …

A cDNA library from the human hepatoma cell line Hep G2 was prepared in the expression
vector lambda gt11. Using specific antibodies, a cDNA clone containing the entire coding …

With few exceptions, receptor‐mediated endocytosis of specific ligands is mediated through
clustering of receptor‐ligand complexes in coated pits on the cell surface, followed by …

Receptor-mediated endocytosis of specific ligands is mediated through clustering of
receptor-ligand complexes in coated pits on the cell surface, followed by internalization of …

We have used combinations of subcellular fractionation, specific cytochemical tracers, and
quantitative immunoadsorption to determine when, where, and in which intracellular …

We used high-resolution immunocytochemistry on ultrathin frozen sections labeled with
colloidal gold to study the subcellular distribution of the asialoglycoprotein receptor in rat …