Tolerance of hypothalamic beta-endorphin neurons to mu-opioid receptor activation after chronic morphine.

GE Zhang, AH Lagrange, OK Rønnekleiv… - Journal of Pharmacology …, 1996 - ASPET
The mu-opioid receptor is an autoreceptor on hypothalamic beta-endorphin neurons that
when activated inhibits cell firing via increasing an inwardly rectifying potassium …

Opioids hyperpolarize β-endorphin neurons via μ-receptor activation of a potassium conductance

MJ Kelly, MD Loose, OK Ronnekleiv - Neuroendocrinology, 1990 - karger.com
Intracellular recordings were made from hypothalamic arcuate (ARC) neurons with biocytin-
filled electrodes under current-and voltage-clamp in slices prepared from ovariectomized …

Tolerance to μ-opioid receptor agonists but not cross-tolerance to γ-aminobutyric acidB receptor agonists in arcuate A12 dopamine neurons with chronic morphine …

EJ Wagner, G Zhang, AH Lagrange… - … of Pharmacology and …, 1997 - ASPET
The present study examined the potential for cross-tolerance development between μ-opioid
and γ-aminobutyric acidBreceptor agonists, in hypothalamic arcuate neurons, resulting from …

The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol

AH Lagrange, OK Ronnekleiv… - Journal of Neuroscience, 1994 - Soc Neuroscience
The mu-opioid agonist DAMGO (Tyr-D-Ala-Gly-MePhe-Gly-ol) hyperpolarizes the majority of
arcuate hypothalamic (ARC) neurons by opening an inwardly rectifying potassium …

Direct inhibition by opioid peptides of neurones located in the ventromedial nucleus of the guinea pig hypothalamus

S Charpak, M Dubois-Dauphin, M Raggenbass… - Brain research, 1988 - Elsevier
In slices of guinea pig brain, intracellular recordings were obtained from neurones of the
ventromedial nucleus of the hypothalamus (VMH).[d-Ala 2, NMePhe 4, Gly-ol 5] enkephalin …

Protein kinase a maintains cellular tolerance tomu opioid receptor agonists in hypothalamic neurosecretory cells with chronic morphine treatment: Convergence on a …

EJ Wagner, OK Rønnekleiv, MJ Kelly - Journal of Pharmacology and …, 1998 - ASPET
The present study examined protein kinase A (PKA) and protein kinase C (PKC)
involvement in the maintenance of cellular tolerance to mu opioid receptor agonists resulting …

Pre‐ and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro

PJ Emmerson, RJ Miller - The Journal of Physiology, 1999 - Wiley Online Library
1 Using whole‐cell patch clamp recording from neurones in an in vitro slice preparation, we
have examined opioid‐and orphanin FQ (OFQ)‐mediated modulation of synaptic …

Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance

MD Loose, MJ Kelly - Brain research, 1990 - Elsevier
Intracellular recordings were made from 48 hypothalamic arcuate (ARC) neurons under
current-and voltage-clamp in slices prepared from female guinea pigs which had been …

[3H]-beta-endorphin binding in rat brain

RA Houghten, N Johnson… - Journal of …, 1984 - Soc Neuroscience
The binding of [3H]-beta-endorphin to rat brain homogenates is complex. Although
Scatchard analysis of saturation studies yields a straight line, detailed competition studies …

Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats

BEH Sumner, JE Coombes, KM Pumford, JA Russell - Neuroscience, 1990 - Elsevier
Morphine, given acutely, inhibits oxytocin secretion in adult female rats, but chronic
intracerebroventricular infusion for five to six days induces tolerance and dependence in the …