A brief review of short tandem repeat mutation
H Fan, JY Chu - Genomics, Proteomics and Bioinformatics, 2007 - academic.oup.com
Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a
repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are …
repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are …
A genomic view of short tandem repeats
M Gymrek - Current opinion in genetics & development, 2017 - Elsevier
Short tandem repeats (STRs) are some of the fastest mutating loci in the genome. Tools for
accurately profiling STRs from high-throughput sequencing data have enabled genome …
accurately profiling STRs from high-throughput sequencing data have enabled genome …
Accurate typing of short tandem repeats from genome-wide sequencing data and its applications
Short tandem repeats (STRs) are implicated in dozens of human genetic diseases and
contribute significantly to genome variation and instability. Yet profiling STRs from short-read …
contribute significantly to genome variation and instability. Yet profiling STRs from short-read …
[HTML][HTML] Recent advances in the detection of repeat expansions with short-read next-generation sequencing
M Bahlo, MF Bennett, P Degorski, RM Tankard… - …, 2018 - ncbi.nlm.nih.gov
Short tandem repeats (STRs), also known as microsatellites, are commonly defined as
consisting of tandemly repeated nucleotide motifs of 2–6 base pairs in length. STRs appear …
consisting of tandemly repeated nucleotide motifs of 2–6 base pairs in length. STRs appear …
[HTML][HTML] Characterization of genome-wide STR variation in 6487 human genomes
Y Shi, Y Niu, P Zhang, H Luo, S Liu, S Zhang… - Nature …, 2023 - nature.com
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome.
Many STR loci have been associated with a range of human genetic disorders. However …
Many STR loci have been associated with a range of human genetic disorders. However …
Tandem repeats mediating genetic plasticity in health and disease
AJ Hannan - Nature Reviews Genetics, 2018 - nature.com
Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that
distinguish them from other genetic variants, including the fact that they are more liable to …
distinguish them from other genetic variants, including the fact that they are more liable to …
The biological effects of simple tandem repeats: lessons from the repeat expansion diseases
K Usdin - Genome research, 2008 - genome.cshlp.org
Tandem repeats are common features of both prokaryote and eukaryote genomes, where
they can be found not only in intergenic regions but also in both the noncoding and coding …
they can be found not only in intergenic regions but also in both the noncoding and coding …
[HTML][HTML] Population-scale sequencing data enable precise estimates of Y-STR mutation rates
Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human
genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by …
genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by …
Sequencing and characterizing short tandem repeats in the human genome
HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
[HTML][HTML] Detecting expansions of tandem repeats in cohorts sequenced with short-read sequencing data
RM Tankard, MF Bennett, P Degorski… - The American Journal of …, 2018 - cell.com
Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic.
These can present with overlapping clinical phenotypes, making molecular diagnosis …
These can present with overlapping clinical phenotypes, making molecular diagnosis …