A brief review of short tandem repeat mutation

H Fan, JY Chu - Genomics, Proteomics and Bioinformatics, 2007 - academic.oup.com
Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a
repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are …

A genomic view of short tandem repeats

M Gymrek - Current opinion in genetics & development, 2017 - Elsevier
Short tandem repeats (STRs) are some of the fastest mutating loci in the genome. Tools for
accurately profiling STRs from high-throughput sequencing data have enabled genome …

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

A Fungtammasan, G Ananda, SE Hile, MSW Su… - Genome …, 2015 - genome.cshlp.org
Short tandem repeats (STRs) are implicated in dozens of human genetic diseases and
contribute significantly to genome variation and instability. Yet profiling STRs from short-read …

[HTML][HTML] Recent advances in the detection of repeat expansions with short-read next-generation sequencing

M Bahlo, MF Bennett, P Degorski, RM Tankard… - …, 2018 - ncbi.nlm.nih.gov
Short tandem repeats (STRs), also known as microsatellites, are commonly defined as
consisting of tandemly repeated nucleotide motifs of 2–6 base pairs in length. STRs appear …

[HTML][HTML] Characterization of genome-wide STR variation in 6487 human genomes

Y Shi, Y Niu, P Zhang, H Luo, S Liu, S Zhang… - Nature …, 2023 - nature.com
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome.
Many STR loci have been associated with a range of human genetic disorders. However …

Tandem repeats mediating genetic plasticity in health and disease

AJ Hannan - Nature Reviews Genetics, 2018 - nature.com
Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that
distinguish them from other genetic variants, including the fact that they are more liable to …

The biological effects of simple tandem repeats: lessons from the repeat expansion diseases

K Usdin - Genome research, 2008 - genome.cshlp.org
Tandem repeats are common features of both prokaryote and eukaryote genomes, where
they can be found not only in intergenic regions but also in both the noncoding and coding …

[HTML][HTML] Population-scale sequencing data enable precise estimates of Y-STR mutation rates

T Willems, M Gymrek, GD Poznik, C Tyler-Smith… - The American Journal of …, 2016 - cell.com
Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human
genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by …

Sequencing and characterizing short tandem repeats in the human genome

HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …

[HTML][HTML] Detecting expansions of tandem repeats in cohorts sequenced with short-read sequencing data

RM Tankard, MF Bennett, P Degorski… - The American Journal of …, 2018 - cell.com
Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic.
These can present with overlapping clinical phenotypes, making molecular diagnosis …