Epidermal growth factor receptor (EGFR) is a target of colon cancer therapy, but the effects
of this therapy on the tumor microenvironment remain poorly understood. Our in vivo studies …

Background: Tumor environment has been recognized to affect cancer cell progression,
such as tumor-associated macrophages. However, increasing evidences suggest that tumor …

Aims Cetuximab improves the survival of patients with advanced colorectal cancer (CRC).
However, how cetuximab affects the tumor microenvironment has not been sufficiently …

Epidermal growth factor receptor (EGFR) signaling is a known mediator of colorectal
carcinogenesis. Studies have focused on the role of EGFR signaling in epithelial cells …

Purpose: In a recent randomized phase III clinical trial in metastatic colorectal cancer
patients, the addition of the anti-epidermal growth factor receptor (EGFR) monoclonal …

Macrophages play a crucial role in tumorigenesis depending upon the phenotype of
macrophages found in tumor microenvironments. To date, how the tumor microenvironment …

The interactions between cancer cells and their microenvironment are crucial for malignant
progression, as they modulate invasion-related activities. Tumor-associated macrophages …

Abstract Epidermal Growth Factor Receptor (EGFR) activates a robust signalling network to
which colon cancer tumours often become addicted. Cetuximab, one of the monoclonal …

Fibroblast growth factor receptor 2 (FGFR2) is frequently activated by overexpression or
mutation, and an abnormal fibroblast growth factor (FGF)/FGFR signaling pathway is …

Introduction Tumor cells invade and spread through a procedure termed as epithelial-to-
mesenchymal cell transition (EMT). EMT is triggered by any alterations in the genes that …