Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce
excessive amounts of extracellular matrix components such as collagen type I. However, the …

Pathologic accumulation of fibroblasts in pulmonary fibrosis appears to depend on their
invasion through basement membranes and extracellular matrices. Fibroblasts from the …

Pulmonary fibrosis is a devastating disorder that is resistant to treatment. Patients with
idiopathic pulmonary fibrosis (IPF) have a median survival of 4 to 5 yr after onset of …

Lung fibrosis is the final result of a large number of disorders and is usually considered an
irreversible process. However, some evidence suggests that fibrosis could eventually be …

The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in
which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and …

Background Pulmonary fibrosis is a progressive and lethal disease characterized by
damage to the lung parenchyma with excess extracellular matrix deposition. The …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …

Rationale: Lung fibroblasts are key mediators of fibrosis resulting in accumulation of
excessive interstitial collagen and extracellular matrix, but their origins are not well defined …

A progressive fibrosing phenotype is critical in several lung diseases. It is irreversible and
associated with early patient mortality. Growing evidence has revealed pulmonary …

Single-dose intratracheal bleomycin has been instrumental for understanding fibrotic lung
remodeling, but fails to recapitulate several features of idiopathic pulmonary fibrosis (IPF) …