Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry
and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of …

Monocytes represent a heterogeneous population of primary immune effector cells. At least
three different subsets can be distinguished based on expression of the low-affinity FcγRIII …

CD8-mediated inflammatory central nervous system disorders : Current Opinion in Neurology
CD8-mediated inflammatory central nervous system disorders : Current Opinion in Neurology …

Background Tissue-resident antigen-presenting cells (APC) exert a major influence on the
local immune environment. Microglia are resident myeloid cells in the central nervous …

Background Clinical trials evaluating anti-CD20-mediated B-cell depletion in multiple
sclerosis (MS) and neuromyelitis optica (NMO) generated encouraging results. Our recent …

Multiple sclerosis is a chronic disabling CNS disorder, characterized by autoimmune
inflammatory demyelination and neurodegeneration. CD200, broadly expressed on neurons …

Recent studies demonstrated that primary immune responses can be induced within the
brain depending on vessel-associated cells expressing markers of dendritic cells (DC) …

In T-cell-mediated autoimmune diseases of the central nervous system (CNS), CD4 T cells
have long been regarded as the only pathogenetically relevant T-cell population. However …

DC in the CNS have emerged as the major rate‐limiting factor for immune invasion and
subsequent neuroinflammation during EAE. The mechanism of how this is regulated by …

Cytotoxic CD8+ T cells are increasingly recognized as key players in various inflammatory
and degenerative central nervous system (CNS) disorders. CD8+ T cells are believed to …