Several lines of evidence support a key role for CD8+ T cells in central nervous system
tissue damage of patients with multiple sclerosis. However, the precise phenotype of the …

The central nervous system (CNS) is under close surveillance by immune cells, which
mediate tissue homeostasis, protection, and repair. Conversely, in neuroinflammation …

Dendritic cells (DCs) appear in higher numbers within the CNS as a consequence of
inflammation associated with autoimmune disorders, such as multiple sclerosis, but the …

Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …

CD24 is a cell surface glycoprotein that is expressed on both immune cells and cells of the
CNS. We have previously shown that CD24 is required for the induction of experimental …

Inflammation is a biological process that dynamically alters the surrounding
microenvironment, including participating immune cells. As a well‐protected organ …

CD8 T cells are emerging as important players in multiple sclerosis (MS) pathogenesis,
although their direct contribution to tissue damage is still debated. To assess whether …

Central nervous system (CNS) inflammation occurs in a large number of neurological
diseases. The type and magnitude of CNS inflammation, as well as the T‐cell contribution …

Trafficking of antigen-presenting cells into the CNS is essential for lymphocyte reactivation
within the CNS compartment. Although perivascular dendritic cells found in inflammatory …

Immune surveillance of the central nervous system (CNS) by T cells is important to keep
CNS-trophic viruses in a latent state, yet our knowledge of the characteristics of CNS …