[HTML][HTML] Recent structural advances towards understanding of the bacterial type III secretion injectisome

J Jenkins, LJ Worrall, NCJ Strynadka - Trends in Biochemical Sciences, 2022 - cell.com
The bacterial injectisome is a structurally conserved, syringe-shaped nanomachine that
spans the Gram-negative envelope and forms a continuous channel for type III secretion of …

Structural overview of the bacterial injectisome

LJ Worrall, E Lameignere, NCJ Strynadka - Current opinion in microbiology, 2011 - Elsevier
The bacterial injectisome is a specialized protein-export system utilized by many pathogenic
Gram-negative bacteria for the delivery of virulence proteins into the hosts they infect. This …

The type III secretion injectisome

GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …

Piecing together the type III injectisome of bacterial pathogens

TF Moraes, T Spreter, NCJ Strynadka - Current opinion in structural biology, 2008 - Elsevier
The Type III secretion system is a bacterial 'injectisome'which allows Gram-negative bacteria
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …

Investigating the assembly of the bacterial type III secretion system injectisome by in vivo photocrosslinking

N Singh, S Wagner - International Journal of Medical Microbiology, 2019 - Elsevier
Virulence-associated type III secretion systems serve the injection of bacterial effector
proteins into eukaryotic host cells. These effector proteins modulate host cell biology in order …

T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly

J Hu, LJ Worrall, M Vuckovic, C Hong, W Deng… - Nature …, 2019 - nature.com
The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …

Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

J Hu, LJ Worrall, C Hong, M Vuckovic… - Nature …, 2018 - nature.com
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …

Recent insights into type-3 secretion system injectisome structure and mechanism of human enteric pathogens

P Chen, MB Goldberg - Current opinion in microbiology, 2023 - Elsevier
Type-3 secretion system injectisomes are multiprotein complexes that translocate bacterial
effector proteins from the cytoplasm of gram-negative bacteria directly into the cytosol of …

Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome

EZ Guo, JE Galán - … of the National Academy of Sciences, 2021 - National Acad Sciences
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …

On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome

BJE Lyons, NCJ Strynadka - Medchemcomm, 2019 - pubs.rsc.org
The type III secretion system injectisome is a syringe-like multimembrane spanning
nanomachine that is essential to the pathogenicity but not viability of many clinically relevant …