Family physicians are the primary and sometimes only health care resource for families
affected by sickle cell disease. Recently published guidelines provide important …

Importance Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly
100 000 individuals in the United States and is associated with many acute and chronic …

Purpose: To familiarize primary care providers (PCPs) with the pathophysiological
processes, diagnostic evaluation, and medical management of sickle hemoglobinopathies …

The application of evidence-based medicine to the management of adults with sickle cell
disease (SCD) is currently primarily driven by clinical expertise and patient preference, as …

Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The
pathophysiology involves abnormalities not just in red blood cells but also vascular …

Introduction: Advances in research, medical care, and public health practice have led to
individuals with sickle cell disease (SCD) living into adulthood. However, premature …

Proper management of sickle cell anemia (SCA) begins with establishing the correct
diagnosis early in life, ideally during the newborn period. The identification of affected …

Sickle cell disease remains a major public health concern in sub-Saharan Africa, Europe,
and the United States. The survival rate of children and adolescents has increased …

Background: Hydroxyurea is the only approved drug for treatment of sickle cell disease.
Objective: To synthesize the published literature on the efficacy, effectiveness, and toxicity of …

OBJECTIVE: Sickle cell disease (SCD) affects 70 000 to 100 000 people in the United
States, and 2000 infants are born with the disease each year. The purpose of this study was …