Obesity represents a risk factor for certain types of cancer. Leptin, a hormone predominantly
produced by adipocytes, is elevated in the obese state. In the context of breast cancer, leptin …

Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

There is growing evidence that obesity is a risk factor of cancer incidence and mortality.
Hence, the identification of the mechanistic links between obesity and cancer progression is …

Adipokines represent likely candidates to mediate the increased breast cancer risk and the
enhanced progression associated with obesity. Other contributors to obesity-related cancer …

Obesity is a recently established risk factor for breast cancer incidence and mortality. A
characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin …

Purpose Leptin, an adipose secreted cytokine, is implicated in mammary cancer stem cell
self-renewal and tumor growth in murine mammary tumor virus (MMTV)-Wnt-1 transgenic …

Obesity confers risks to cancer development and progression but the mechanisms
underlying these risks remain unclear. In this study, we identify a role for the obesity cytokine …

Leptin restricts intake of calories as a satiety hormone. It probably stimulates neoplastic
proliferation in breast cancer, too. Growth of malignant cells could be regulated by various …

The adipokine leptin, known for its key role in the control of energy metabolism, has been
shown to be involved in both normal and tumoral mammary growth. One of the hallmarks of …

Obesity is a recently established risk factor for breast cancer incidence and mortality. A
characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin …