Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice
AD Kenney, A Zani, J Kawahara, AC Eddy, XL Wang… - EMBO …, 2023 - embopress.org
Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein that alters cell
membranes to block fusion of viruses. Conflicting reports identified opposing effects of …
membranes to block fusion of viruses. Conflicting reports identified opposing effects of …
[HTML][HTML] Heightened circulating interferon-inducible chemokines, and activated pro-cytolytic Th1-cell phenotype features covid-19 aggravation in the second week of …
C Tincati, ES Cannizzo, M Giacomelli… - Frontiers in …, 2020 - frontiersin.org
Covid-19 features a delayed onset of critical illness occurring approximately one week from
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …
[HTML][HTML] Inflammation and antiviral immune response associated with severe progression of COVID-19
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …
[HTML][HTML] COVID-19: The emerging immunopathological determinants for recovery or death
Hyperactivation of the host immune system during infection by SARS-CoV-2 is the leading
cause of death in COVID-19 patients. It is also evident that patients who develop …
cause of death in COVID-19 patients. It is also evident that patients who develop …
[HTML][HTML] SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70
H Jiang, H Zhang, Q Meng, J Xie, Y Li… - Cellular & molecular …, 2020 - nature.com
COVID-19 is caused by SARS-CoV-2. 1 As of July 16th, 2020, there were 13,579,581
diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally …
diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally …
[HTML][HTML] Type I interferons in COVID-19 pathogenesis
Simple Summary The innate antiviral immune response is essential to limit virus replication
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …
[HTML][HTML] SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
Y Zheng, J Deng, L Han, MW Zhuang, Y Xu… - Signal transduction and …, 2022 - nature.com
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate
network of antiviral host responses to establish infection and spread. The nucleic acid …
network of antiviral host responses to establish infection and spread. The nucleic acid …
[HTML][HTML] Immune evasion of SARS-CoV-2 from interferon antiviral system
YQ Min, M Huang, X Sun, F Deng, H Wang… - Computational and …, 2021 - Elsevier
The on-going pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and …
[HTML][HTML] Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells
Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an
unprecedented worldwide health problem that requires concerted and global approaches to …
unprecedented worldwide health problem that requires concerted and global approaches to …