Platelets are known to play a central role in primary hemostasis as well as in the
pathophysiology of thrombotic disorders. However, in addition to hemostasis, platelets are …

Myeloid cells, including monocytes and macrophages participate in steady state immune
homeostasis and help mount the adaptive immune response during infection. The function …

Pulmonary hypertension (PH) is a pathophysiological disorder that can complicate most
cardiovascular and respiratory diseases and may involve multiple clinical conditions, but its …

INTRODUCTION: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by
pulmonary arteriolar narrowing and degeneration associated with in situ thrombosis. We …

Biomedical advances over the last decade have identified the central role of proliferative
pulmonary arterial smooth muscle cells (PASMCs) in the development of pulmonary …

Many pathophysiologic processes of pulmonary arterial hypertension (PAH), namely, excess
vasoconstriction, vascular remodeling and in situ thrombosis, involve the coagulation …

Platelets are important actors of cardiovascular diseases (CVD). Current antiplatelet drugs
that inhibit platelet aggregation have been shown to be effective in CVD treatment. However …

Microparticles (MPs) are phenotypically and functionally heterogeneous population of
microvesicles. Although MP formation represents a physiological phenomenon. A multitude …

Pulmonary arterial hypertension (PAH) is a complex obliterative vascular disease. It remains
deadly despite an explosion of basic research over the past 20 years that identified myriads …

There is increasing research on and clinical interest in the physiological role played by
platelet microparticles (PMPs). PMPs are 0.1–1-μm fragments shed from plasma …