Aims/hypothesis Hyperglycaemia is a primary cause of vascular complications in diabetes. A
hallmark of these vascular complications is endothelial cell dysfunction, which is partly due …

Background Hyperglycemia is a primary cause of premature vascular disease. Endothelial
cell dysfunction characterized by diminished endothelium-dependent relaxations is likely to …

Incubation of endothelial cells in vitro with high concentrations of glucose activates protein
kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as …

Hyperglycemia is considered a primary cause of diabetic vascular complications. A hallmark
of vascular disease is endothelial cell dysfunction characterized by diminished nitric-oxide …

Previous studies indicate that endothelial nitric oxide synthase (eNOS) function is impaired
in diabetes as a result of increased vascular generation of reactive oxygen species. We …

Angiotensin II (Ang II) levels are increased in patients with diabetes, but mechanisms
underlying its contribution to diabetic vascular diseases are incompletely understood. We …

Elevated oxidative stress plays a key role in the development of atherosclerosis and
endothelial dysfunction in diabetes-associated vascular disease. Glucose-induced changes …

Background Endothelial dysfunction precedes pathogenesis of vascular complications in
diabetes. In recent years, the mechanisms of endothelial dysfunction were investigated to …

Objective—Diabetes mellitus is associated with increased oxidative stress, which induces
oxidation of tetrahydrobiopterin (BH4) in vessel wall. Without enough BH4, eNOS is …

Although the etiology of vascular dysfunction in diabetes has been extensively investigated
in both humans as well as animal models of human diabetes, the relative importance of the …