Examining the potential of developing and implementing use of adiponectin-targeted therapeutics for metabolic and cardiovascular diseases

Y Liu, V Vu, G Sweeney - Frontiers in endocrinology, 2019 - frontiersin.org
Cardiometabolic diseases encompass those affecting the heart and vasculature as well as
other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver …

Adiponectin and cardiovascular disease: mechanisms and new therapeutic approaches

G Siasos, D Tousoulis, C Kollia… - Current medicinal …, 2012 - ingentaconnect.com
Adiponectin is an abundant plasma protein secreted from adipocytes. Its role in energy
homeostasis is well-known, including the regulation of hydrocarbons and lipids metabolism …

[HTML][HTML] Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges

X Lei, S Qiu, G Yang, Q Wu - Genes & Diseases, 2023 - Elsevier
Metabolic cardiovascular diseases have become a global health concern, and some of their
risk factors are linked to several metabolic disorders. They are the leading causes of death …

Back to the heart: the protective role of adiponectin

C Caselli, A D'amico, M Cabiati, T Prescimone… - Pharmacological …, 2014 - Elsevier
Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence
of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of …

Adiponectin and cardiovascular health: an update

X Hui, KSL Lam, PM Vanhoutte… - British journal of …, 2012 - Wiley Online Library
The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

The role of adiponectin in maintaining metabolic homeostasis

SC Adiyaman, M Ozer, BO Saydam… - Current Diabetes …, 2020 - ingentaconnect.com
Background: Adiponectin is an adipocyte-derived cytokine closely associated with obesity,
altered body adipose tissue distribution, insulin resistance, and cardiovascular diseases …

Therapeutic perspectives for adiponectin: an update

F YL Li, K SL Lam, A Xu - Current medicinal chemistry, 2012 - ingentaconnect.com
In obesity, the expansion of dysfunctional adipose tissue leads to augmented production of
pro-inflammatory adipokines that mediate metabolic changes through their paracrine and/or …

Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies

S Shetty, CM Kusminski, PE Scherer - Trends in pharmacological sciences, 2009 - cell.com
Adiponectin is a secretory protein predominantly expressed by adipocytes and released at a
high rate into circulation. The ease with which the levels of adiponectin can be measured …

Modulation of adiponectin as a potential therapeutic strategy

S Lim, MJ Quon, KK Koh - Atherosclerosis, 2014 - Elsevier
Adiponectin is produced predominantly by adipocytes and plays an important role in
metabolic and cardiovascular homeostasis through its insulin-sensitizing actions and anti …

Adiponectin synthesis, secretion and extravasation from circulation to interstitial space

SC da Silva Rosa, M Liu, G Sweeney - Physiology, 2021 - journals.physiology.org
Adiponectin, an adipokine that circulates as multiple multimeric complexes at high levels in
serum, has antidiabetic, anti-inflammatory, antiatherogenic, and cardioprotective properties …