Heparan sulfate (HS) plays critical roles in a variety of developmental, physiological, and
pathogenic processes due to its ability to interact in a structure-dependent manner with …

Heparan sulfate mediates numerous complex biological processes. Its action critically
depends on the amount and the positions of O-sulfate groups (iduronyl 2-O-sulfates …

Chondroitin sulfate is an important and major component of articular cartilage, where it
occurs as part of the large proteoglycan, aggrecan. In the early stages of joint disease, both …

Based on sequence homology with the recently cloned human chondroitin synthase, we
identified a novel β1, 4-N-acetylgalactosaminyltransferase, which consisted of 532 amino …

Heparan sulfate (HS) interactions with secreted morphogens such as fibroblast growth
factors, hedgehogs, and Wnts are essential for embryonic development. Formation of …

We found a novel glycosyltransferase gene having a hypothetical β1, 4-
galactosyltransferase motif (GenBank TM accession number AB081516) by a BLAST search …

Osteoarthritis is a chronic, debilitating joint disease characterized by progressive destruction
of articular cartilage. Recently, a number of studies have identified a chondroprogenitor cell …

In contrast to the functional role of heparan sulfate proteoglycans (HSPGs), the importance
of chondroitin sulfate proteoglycans (CSPGs) in modulating signaling pathways involving …

Cell surface heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans have been
implicated in a multitude of biological processes, including embryonic implantation, tissue …

Syndecans are single-pass integral membrane components that serve as co-receptors for
growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We …