[HTML][HTML] Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality
H Habuchi, N Nagai, N Sugaya, F Atsumi… - Journal of Biological …, 2007 - ASBMB
Heparan sulfate (HS) plays critical roles in a variety of developmental, physiological, and
pathogenic processes due to its ability to interact in a structure-dependent manner with …
pathogenic processes due to its ability to interact in a structure-dependent manner with …
[HTML][HTML] Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity
P Jemth, E Smeds, AT Do, H Habuchi, K Kimata… - Journal of Biological …, 2003 - ASBMB
Heparan sulfate mediates numerous complex biological processes. Its action critically
depends on the amount and the positions of O-sulfate groups (iduronyl 2-O-sulfates …
depends on the amount and the positions of O-sulfate groups (iduronyl 2-O-sulfates …
Chondroitin sulfate and joint disease
T Hardingham - Osteoarthritis and cartilage, 1998 - Elsevier
Chondroitin sulfate is an important and major component of articular cartilage, where it
occurs as part of the large proteoglycan, aggrecan. In the early stages of joint disease, both …
occurs as part of the large proteoglycan, aggrecan. In the early stages of joint disease, both …
[HTML][HTML] Molecular Cloning and Expression of Human ChondroitinN-Acetylgalactosaminyltransferase: THE KEY ENZYME FOR CHAIN INITIATION AND ELONGATION …
T Uyama, H Kitagawa, J Tamura, K Sugahara - Journal of Biological …, 2002 - ASBMB
Based on sequence homology with the recently cloned human chondroitin synthase, we
identified a novel β1, 4-N-acetylgalactosaminyltransferase, which consisted of 532 amino …
identified a novel β1, 4-N-acetylgalactosaminyltransferase, which consisted of 532 amino …
Differential expression of heparan sulfate 6‐O‐sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis
J Sedita, K Izvolsky, WV Cardoso - … Dynamics: An Official …, 2004 - Wiley Online Library
Heparan sulfate (HS) interactions with secreted morphogens such as fibroblast growth
factors, hedgehogs, and Wnts are essential for embryonic development. Formation of …
factors, hedgehogs, and Wnts are essential for embryonic development. Formation of …
[HTML][HTML] Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid …
M Gotoh, T Sato, T Akashima, H Iwasaki… - Journal of Biological …, 2002 - ASBMB
We found a novel glycosyltransferase gene having a hypothetical β1, 4-
galactosyltransferase motif (GenBank TM accession number AB081516) by a BLAST search …
galactosyltransferase motif (GenBank TM accession number AB081516) by a BLAST search …
Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells
Osteoarthritis is a chronic, debilitating joint disease characterized by progressive destruction
of articular cartilage. Recently, a number of studies have identified a chondroprogenitor cell …
of articular cartilage. Recently, a number of studies have identified a chondroprogenitor cell …
Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate
In contrast to the functional role of heparan sulfate proteoglycans (HSPGs), the importance
of chondroitin sulfate proteoglycans (CSPGs) in modulating signaling pathways involving …
of chondroitin sulfate proteoglycans (CSPGs) in modulating signaling pathways involving …
Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling …
KJ Manton, DFM Leong, SM Cool, V Nurcombe - Stem cells, 2007 - academic.oup.com
Cell surface heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans have been
implicated in a multitude of biological processes, including embryonic implantation, tissue …
implicated in a multitude of biological processes, including embryonic implantation, tissue …
Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis
Syndecans are single-pass integral membrane components that serve as co-receptors for
growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We …
growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We …