[HTML][HTML] Heparan sulfate as a regulator of endochondral ossification and osteochondroma development
K Jochmann, V Bachvarova, A Vortkamp - Matrix Biology, 2014 - Elsevier
Most elements of the vertebrate skeleton are formed by endochondral ossification. This
process is initiated with mesenchymal cells that condense and differentiate into …
process is initiated with mesenchymal cells that condense and differentiate into …
Oversulfated chondroitin sulfate‐E binds to BMP‐4 and enhances osteoblast differentiation
T Miyazaki, S Miyauchi, A Tawada… - Journal of cellular …, 2008 - Wiley Online Library
Small leucine‐rich proteoglycans, such as biglycan, and their side chain sulfated
glycosaminoglycans (GAGs), have been suggested to be involved in bone formation and …
glycosaminoglycans (GAGs), have been suggested to be involved in bone formation and …
Heparan sulfate fine structure and specificity of proteoglycan functions
H Nakato, K Kimata - Biochimica Et Biophysica Acta (BBA)-General …, 2002 - Elsevier
Heparan sulfate chains have markedly heterogeneous structures in which distinct patterns of
sulfation determine the binding specificity for ligand proteins. These “fine structures” of …
sulfation determine the binding specificity for ligand proteins. These “fine structures” of …
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1
K Uchimura, M Morimoto-Tomita, A Bistrup, J Li… - BMC biochemistry, 2006 - Springer
Background Heparin/heparan sulfate (HS) proteoglycans are found in the extracellular
matrix (ECM) and on the cell surface. A considerable body of evidence has established that …
matrix (ECM) and on the cell surface. A considerable body of evidence has established that …
Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain
The primary macrophage growth factor, colony-stimulating factor-1 (CSF-1), is homodimeric
and exists in 3 biologically active isoforms: a membrane-spanning, cell-surface glycoprotein …
and exists in 3 biologically active isoforms: a membrane-spanning, cell-surface glycoprotein …
Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation
J Presto, M Thuveson, P Carlsson… - Proceedings of the …, 2008 - National Acad Sciences
Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology
through interactions with protein ligands. The interactions depend on HS structure, which is …
through interactions with protein ligands. The interactions depend on HS structure, which is …
Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease
C Malavaki, S Mizumoto, N Karamanos… - Connective tissue …, 2008 - Taylor & Francis
Chondroitin sulfate (CS) dermatan sulfate (DS), and CS/DS hybrid chains are biologically
active like heparan sulfate, and structurally the most complex species of the …
active like heparan sulfate, and structurally the most complex species of the …
Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division
T Izumikawa, H Kitagawa, S Mizuguchi… - Journal of biological …, 2004 - ASBMB
Chondroitin polymerization was first demonstrated in vitro when human chondroitin
synthase (ChSy) was coexpressed with human chondroitin polymerizing factor (ChPF) …
synthase (ChSy) was coexpressed with human chondroitin polymerizing factor (ChPF) …
Chondroitin sulfate synthase-2: molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase …
T Yada, M Gotoh, T Sato, M Shionyu, M Go… - Journal of Biological …, 2003 - ASBMB
Chondroitin sulfate is found in a variety of tissues as proteoglycans and consists of repeating
disaccharide units of N-acetylgalactosamine and glucuronic acid residues with sulfate …
disaccharide units of N-acetylgalactosamine and glucuronic acid residues with sulfate …
Heparan sulfate biosynthesis: regulation and variability
Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …