Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo
GK Hagos, RE Carroll, T Kouznetsova, Q Li… - Molecular cancer …, 2007 - AACR
Chemopreventive agents in colorectal cancer possess either antiproliferative or anti-
inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 …
inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 …
NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future
S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …
Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl) diazen-1-ium-1, 2-diolate (NONO-ASA) as safe …
M Chattopadhyay, CA Velazquez, A Pruski… - … of Pharmacology and …, 2010 - ASPET
Chronic inflammation is an underlying etiological factor in carcinogenesis; nonsteroidal anti-
inflammatory drugs (NSAIDs) and their chemically modified NO-releasing prodrugs (NO …
inflammatory drugs (NSAIDs) and their chemically modified NO-releasing prodrugs (NO …
Blocking the endogenous formation of N-nitroso compounds and related carcinogens.
H Bartsch, N Frank - IARC scientific publications, 1996 - europepmc.org
Humans are exposed to a wide range of nitrogen-containing compounds and nitrosating
agents, such as nitrite, nitrate and nitrogen oxides (NOx), that can react in vivo to form …
agents, such as nitrite, nitrate and nitrogen oxides (NOx), that can react in vivo to form …
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs …
JL Williams, S Borgo, I Hasan, E Castillo, F Traganos… - Cancer Research, 2001 - AACR
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …
Gene expression profiles of NO-and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways
Abstract Nitric oxide (NO) synthase 2 (NOS2), a major inflammatory protein, modulates
disease progression via NO in a number of pathologies, including cancer. The role of NOS2 …
disease progression via NO in a number of pathologies, including cancer. The role of NOS2 …
iNOS-selective inhibitors for cancer prevention: promise and progress
NB Janakiram, CV Rao - Future medicinal chemistry, 2012 - Future Science
Nitric oxide (NO) is involved in various physiological functions and its role in tumorigenesis
has been well studied. A large majority of human and experimental tumors appear to …
has been well studied. A large majority of human and experimental tumors appear to …
NO-NSAIDs: from inflammatory mediators to clinical readouts
S Fiorucci, E Antonelli - Inflammation & Allergy-Drug Targets …, 2006 - ingentaconnect.com
Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase (COX)-2 selective
inhibitors (COXIBs) are widely used drugs. However, their use is hampered by …
inhibitors (COXIBs) are widely used drugs. However, their use is hampered by …
Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome
EN Pierce, SC Piyankarage, T Dunlap… - Chemical research in …, 2016 - ACS Publications
Electrophilic reactive intermediates resulting from drug metabolism have been associated
with toxicity and off-target effects and in some drug discovery programs trigger NO-GO …
with toxicity and off-target effects and in some drug discovery programs trigger NO-GO …
Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines*
Although non steroidal antiinflammatory drugs (NSAIDs) have been shown to be effective as
chemopreventive agents, important side-effects limit their clinical use. A promising novel …
chemopreventive agents, important side-effects limit their clinical use. A promising novel …