NO-donating aspirin (NO-ASA), a novel pharmacological agent currently undergoing clinical
testing, consists of ASA to which a nitrate group is covalently linked via a spacer molecule …

Clinical and preclinical studies provide strong evidence that nonsteroidal anti-inflammatory
drugs (NSAIDs) can prevent numerous types of cancers, especially colorectal cancer …

Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical
functions in the body. There are markedly conflicting findings in the literature regarding the …

Nitric oxide (NO) is a short-lived pleiotropic regulator and is required for numerous
pathophysiological functions, including macrophage-mediated immunity and cancer. It is a …

Significance: As one-electron reduced molecule of nitric oxide (NO), nitroxyl (HNO) has
gained enormous attention because of its novel physiological or pharmacological …

The promising therapeutic potential of the NO-donating hybrid aspirin prodrugs (NO-ASA)
includes induction of chemopreventive mechanisms and has been reported in almost 100 …

Nitric oxide (NO) regulates protein function by S-nitrosylation of cysteine to form
nitrosothiols. Nitrosothiols are highly susceptible to nonenzymatic degradation by cytosolic …

Nitric oxide (NO), a 'magic'free radical gas molecule, has been shown to be involved in
numerous physiological and pathophysiological processes. Previously, together with its …

Recent evidence from experimental and clinical studies links the development of
intratumoral hypoxia and oxidative stress with malignant progression. Cellular adaptation …

Piroxicam dose-and time-dependently induced gastric lesions in rats. The piroxicam-
induced gastric lesions, both in acute (18-h) and in sub-chronic (3-and 14-day) treatments …