Background: Hypoxia in tumors is associated with malignant progression, metastatic spread,
and increased resistance to radiotherapy and chemotherapy. Molecular O2 is required for …

Nitric oxide-releasing aspirin (NO-ASA) is emerging as a potentially important
chemopreventive agent against colon cancer. We examined in HT-29 human colon …

A new class of nitric oxide (NO•)-releasing nonsteroidal anti-inflammatory drugs (NONO-
NSAIDs) were developed in recent years and have shown promising potential as NSAID …

Preclinical studies have shown that nitric oxide (NO)–donating nonsteroidal anti-
inflammatory drugs possess anticancer activities. Here, we report in vitro and in vivo studies …

Protein S-nitrosylation is now recognized as a ubiquitous regulatory mechanism. Like any
post-translational modifications, S-nitrosylation is critical for the control of numerous cellular …

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the
role of NO is decided by its concentration present in physiological environments. NO either …

Nitroxyl (HNO) donors exhibit promising pharmacological characteristics for treatment of
cardiovascular disorders, cancer, and alcoholism. However, whether HNO also serves as an …

Nitric oxide (NO) is a gaseous molecule endowed with diverse biological functions, offering
vast potential in the realm of cancer treatment. Considerable efforts have been dedicated to …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the widely used medications all
over the world, indicated for pain, fever, and inflammation. It is now well established that …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have unacceptable morbidity and mortality
due to their gastrointestinal toxicity. Attempts so far to improve the safety profile of NSAIDs …