The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and
potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide …

The objective of this work was to evaluate the biological properties of a new series of nitric
oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol …

S-Nitrosation is a cysteine post-translational modification fundamental to cellular signaling.
This modification regulates protein function in numerous biological processes in the …

Nitric oxide (NO) is an endogenous, diffusible, transcellular messenger shown to affect
regulatory and signaling pathways with impact on cell survival. Exposure to NO can impart …

S-Nitrosothiol (RSNO) formation is one manner by which nitric oxide (• NO) exerts its
biological effects. There are several proposed mechanisms of formation of RSNO in vivo …

Several epidemiological, clinical and experimental studies established nonsteroidal anti-
inflammatory drugs (NSAIDs) as promising cancer chemopreventive agents. Long-term use …

Personalized health care management and optimization of the treatment of disease is
crucial for improving the quality of health. Significant efforts have been made to design and …

In 1989, at the tenth in thc series of meetings on N-nitroso compounds (NNOC) since 1969
organized by the International Agency for Research on Cancer (IARC), Bartsch posed the …

A major emphasis in cancer therapy research is finding mechanisms to enhance the
effectiveness of clinically used chemotherapeutic agents. In this report, we show the effects …