Dysregulation of autophagy contributes to aging and to diseases such as
neurodegeneration, cardiomyopathy, and cancer. The paper by Yang et al.(2010) in this …

Autophagy is a cellular pathway crucial for development, differentiation, survival and
homeostasis. Autophagy can provide protection against aging and a number of pathologies …

The prevalence of obesity is increasing rapidly and is closely associated with a variety of
metabolic diseases. Recent studies have suggested that autophagy is likely to play an …

Obesity is a direct result of the accumulation of white adipose tissue (WAT). In this study, the
role of autophagy in the differentiation of white adipose tissue was studied by deleting the …

Despite growing interest in the relationship between autophagy and systemic metabolism,
how global changes in autophagy affect metabolism remains unclear. Here we show that …

Objectives: Autophagy is a highly regulated process that has an important role in the control
of a wide range of cellular functions, such as organelle recycling, nutrient availability and …

Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins
and damaged organelles, thereby maintaining cellular homeostasis. In addition to …

Autophagy plays a crucial role in the maintenance of cellular nutrient balance and the
function of organelles such as mitochondria or the endoplasmic reticulum, which are …

Insulin is a critical hormone that promotes energy storage in various tissues, as well as
anabolic functions. Insulin resistance significantly reduces these responses, resulting in …

Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic β‐
cells producing insulin. Mitochondrial dysfunction may play a role in both processes of …