Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the
substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS …

Background The objective of this study was to use phase imaging to evaluate brain iron
content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS …

Pathological studies demonstrate a decreased iron content in the substantia nigra (SN)
contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as …

The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa
treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more …

Background: Restless legs syndrome (RLS) is a sensory-movement disorder affecting 5 to
10% of the population. Its etiology is unknown, but MRI analyses and immunohistochemical …

Objectives Altered brain iron homeostasis with regional iron deficiency has been previously
reported in several studies of restless legs syndrome (RLS) patients. Inconsistencies still …

Objective: To assess neuropathology in individuals with restless legs syndrome (RLS).
Methods: A standard neuropathologic evaluation was performed on seven brains from …

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior
CSF study. Using a special MRI measurement (R 2′), the authors assessed regional brain …

OBJECTIVE: Cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) and autopsy
studies have suggested that brain iron may be reduced in restless legs syndrome (RLS) …

Background and Purpose Previous T2 relaxometry studies have provided evidence for
regional brain iron deficiency in patients with restless legs syndrome (RLS). Measurement of …