[HTML][HTML] Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release
M Zhou, A Jacob, N Ho, M Miksa, R Wu, SR Maitra… - Critical Care, 2008 - Springer
Introduction Protein disulfide isomerase (PDI) is an important factor for the protein
modification step in the post-translational event. PDI plays an essential role in cell survival …
modification step in the post-translational event. PDI plays an essential role in cell survival …
[HTML][HTML] DHEA-dependent and organ-specific regulation of TNF-α mRNA expression in a murine polymicrobial sepsis and trauma model
T Barkhausen, F Hildebrand, C Krettek… - Critical Care, 2009 - Springer
Introduction Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis,
while mechanisms of action are not yet fully understood. Therefore, we investigated the …
while mechanisms of action are not yet fully understood. Therefore, we investigated the …
[HTML][HTML] Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients
Y Zhang, J Li, J Lou, Y Zhou, L Bo, J Zhu, K Zhu, X Wan… - Critical care, 2011 - Springer
Introduction Studies on the role of programmed death-1 (PD-1) and its main ligand (PD-L1)
during experimental models of sepsis have shown that the PD-1/PD-L1 pathway plays a …
during experimental models of sepsis have shown that the PD-1/PD-L1 pathway plays a …
[HTML][HTML] Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats
T Iba, T Miyasho - Critical Care, 2008 - Springer
Introduction Anticoagulant therapy attracts much attention for the treatment of severe sepsis
since recent studies have revealed that some anticoagulants have the ability to regulate the …
since recent studies have revealed that some anticoagulants have the ability to regulate the …
Disruption of sarcolemmal dystrophin and β-dystroglycan may be a potential mechanism for myocardial dysfunction in severe sepsis
Methods and results Male C57Bl/6 mice were subjected to sham operation and moderate
(MSI) or severe (SSI) septic injury induced by cecal ligation and puncture (CLP). Using …
(MSI) or severe (SSI) septic injury induced by cecal ligation and puncture (CLP). Using …
The new sepsis marker, sCD14-ST, induction mechanism in the rabbit sepsis models
K Shirakawa, K Naitou, J Hirose, M Nakamura… - critical care, 2010 - Springer
Methods To determine the kinetics of sCD14-ST in the rabbit endotoxin shock model and the
cecal ligation and puncture (CLP) model, we prepared the rabbit sCD14-ST immunoassay …
cecal ligation and puncture (CLP) model, we prepared the rabbit sCD14-ST immunoassay …
[HTML][HTML] Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm
E Futier, JM Constantin, L Combaret, L Mosoni… - Critical Care, 2008 - Springer
Introduction Controlled mechanical ventilation (CMV) induces profound modifications of
diaphragm protein metabolism, including muscle atrophy and severe ventilator-induced …
diaphragm protein metabolism, including muscle atrophy and severe ventilator-induced …
[HTML][HTML] Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors
HP Wu, CC Shih, CY Lin, CC Hua, DY Chuang - Critical Care, 2011 - Springer
Introduction Sepsis-induced immunosuppression may result in death. The mechanisms of
immune suppression include loss of macrophage and monocyte expression of the major …
immune suppression include loss of macrophage and monocyte expression of the major …
[HTML][HTML] Inflammation biomarkers and delirium in critically ill patients
Introduction Delirium is a common occurrence in critically ill patients and is associated with
an increase in morbidity and mortality. Septic patients with delirium may differ from a general …
an increase in morbidity and mortality. Septic patients with delirium may differ from a general …
[HTML][HTML] Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis-pilot study
Background Sepsis remains a major cause of mortality in critical care, for which specific
treatments are lacking. The dysregulated response to infection seen in sepsis includes …
treatments are lacking. The dysregulated response to infection seen in sepsis includes …