Introduction Protein disulfide isomerase (PDI) is an important factor for the protein
modification step in the post-translational event. PDI plays an essential role in cell survival …

Introduction Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis,
while mechanisms of action are not yet fully understood. Therefore, we investigated the …

Introduction Studies on the role of programmed death-1 (PD-1) and its main ligand (PD-L1)
during experimental models of sepsis have shown that the PD-1/PD-L1 pathway plays a …

Introduction Anticoagulant therapy attracts much attention for the treatment of severe sepsis
since recent studies have revealed that some anticoagulants have the ability to regulate the …

Methods and results Male C57Bl/6 mice were subjected to sham operation and moderate
(MSI) or severe (SSI) septic injury induced by cecal ligation and puncture (CLP). Using …

Methods To determine the kinetics of sCD14-ST in the rabbit endotoxin shock model and the
cecal ligation and puncture (CLP) model, we prepared the rabbit sCD14-ST immunoassay …

Introduction Controlled mechanical ventilation (CMV) induces profound modifications of
diaphragm protein metabolism, including muscle atrophy and severe ventilator-induced …

Introduction Sepsis-induced immunosuppression may result in death. The mechanisms of
immune suppression include loss of macrophage and monocyte expression of the major …

Introduction Delirium is a common occurrence in critically ill patients and is associated with
an increase in morbidity and mortality. Septic patients with delirium may differ from a general …

Background Sepsis remains a major cause of mortality in critical care, for which specific
treatments are lacking. The dysregulated response to infection seen in sepsis includes …